MKT-077
MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones.{30109} It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.{30110,30111}
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