FFAR4 (GPR120) (C-Term) Polyclonal Antibody
G Protein-Coupled Receptor (GPR120) is a GPCR activated by the presence of long chain free fatty acids and is expressed in adipocytes and pro-inflammatory macrophages.{13205} The activation of GPR120 results in elevated Ca2+ and activation of the ERK cascade.{13205} ?-3 Fatty acid constituents such as DHA and EPA mediate GPR120 signaling resulting in inhibition of TLR and TNF-? inflammatory signaling pathways in a ?-arrestin2/TAB1 dependent manner.{22326} The anti-inflammatory effects of GPR120 are indirectly involved in promoting insulin secretion and free fatty acid-induced inhibition of apoptosis.{13205} The predicted size for GPR120 is 42.2 kDa and the observed detection is approximately 43 kDa by Western blot.
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FFAR4 (GPR120) (C-Term) Polyclonal Antibody
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FFAR4 (GPR120) (C-Term) Polyclonal Antibody
14265-1
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