Histone H3K4Me2 Monoclonal Antibody

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of histone H3 at lysine 4 (H3K4Me2) is found at active and primed but inactive loci.{47296,47297} It is enriched in gene promoter regions and overlaps with transcription factor binding sites. Low tumor levels of H3K4Me2 positively correlate with decreased overall and disease-free survival in patients with pancreatic cancer.{47298} Cayman's Histone H3K4Me2 Monoclonal Antibody can be used for flow cytometry (FC) and Western blot (WB) applications. The antibody recognizes histone H3K4Me2 at 17 kDa from human samples.