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Induction of HRE activity by cobalt chloride in HRE Leeporter™ - HeLa cells.
Product description

The HRE Leeporter™ Luciferase Reporter cell line is a stably transfected HeLa cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the hypoxia response element (HRE). In response to hypoxia (low oxygen), HREs of target genes are recognized and regulated by the hypoxia-inducible factors (HIFs) which belong to the family of basic helix-loop-helix transcription factors and form heterodimeric complex comprising the alpha subunit (HIF-1 alpha, HIF-2 alpha and HIF-3 alpha) and beta subunit (Arnt1, Arnt2 and Arnt3), among which HIF-1 alpha and HIF-2 alpha are predominant isoforms. Activation of HIFs can also be mediated by chemical hydroxylase inhibitors as hypoxia mimetics including the iron chelator desferrioxamine and cobalt chloride.The HRE induction by cobalt chloride is shown in Figure 1.

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Applications
FUNC
Supplier
Abeomics
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-196°C

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HRE Leeporter HeLa Cell Line

14-118ACL

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HRE Leeporter HeLa Cell Line

14-118ACL

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