IKKy Monoclonal Antibody (Clone 72C627)

Nuclear Factor-?B (NF-?B) is sequestered in the cytoplasm by the I?B family of inhibitory proteins that mask the nuclear localization signal of NF-?B, thereby preventing translocation of NF-?B to the nucleus.{18540} External stimuli such as tumor necrosis factor or other cytokines result in phosphorylation and degradation of I?B, releasing NF-?B dimers. NF-?B dimers subsequently translocate to the nucleus and activate target genes. Synthesis of I?B? is autoregulated.{18541} I?B proteins are phosphorylated by I?B kinase complex consisting of at least three proteins, IKK1/?, IKK2/?, and IKK3/?.{18542,18543,18544,18658,18545} IKK? preferentially interacts with IKK? and is required for activation of IKK complex. IKK? is also known as NF-?B essential modulator (NEMO).{18545} The human T cell leukemia virus type I Tax oncoprotein that activates NF-?B binds neither to IKK? nor IKK?, but complexes directly with IKK?.{18659} This suggests that IKK? may be a key molecule acting as an adapter for oncoprotein specific signaling to IKK? and IKK?.{18659}