Resolvin D4

Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid (Item No. 90310).{18022} It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.{32237,30353} RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection.{30353} With isolated cells, RvD4 promotes phagocytosis of bacteria, opsonized zymosan A, and apoptotic neutrophils by human macrophages.{30353} It also promotes the clearance of apoptotic neutrophils by human fibroblasts.{30353}