trans-Resveratrol-3-O-B-D-Glucuronide

trans-Resveratrol-3-O-?-D-glucuronide is a stilbene that has been found in red wine and an active metabolite of trans-resveratrol (Item No. 70675), a polyphenol with diverse biological activities.{15736} It is primarily produced from trans-resveratrol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1.{51230} trans-Resveratrol-3-O-?-D-glucuronide binds to COX-1 (IC50 = 150 µM).{51227} It reduces the proliferation of several intestinal cancer cell lines (IC50s = 10-16.5 µM) and induces cell cycle arrest at the G0/G1 phase in SW480 intestinal cancer cells when used at a concentration of 30 µM.{51229} trans-Resveratrol-3-O-?-D-glucuronide (200 µM) increases pyruvate production in livers isolated from rats in a model of arthritis induced by complete Freund's adjuvant (CFA).{51228}