MLN8237
MLN8237 is an inhibitor of Aurora A kinase (IC50 = 1 nM).{28846} It is selective for Aurora A over Aurora B kinase (IC50 = 396.5 nM).{65057} MLN8237 (50 nM) induces cell cycle arrest at the G2/M phase and chromosomal misalignment in HCT116 colon cancer cells. It inhibits tumor growth in a Calu-6 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at a dose of 20 mg/kg.{28846}
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