IKK-16 is a potent inhibitor of I?B kinases (IKKs), displaying IC50 values of 200, 40, and 70 nM for IKK?, IKK?, and IKK complex, respectively, in cell-free assays.{29522} It is effective in cells and in animals and has been used delineate the role of NF-?B signaling in diverse contexts.{29517,29521,29518,29519} IKK-16 has also been reported to inhibit protein kinase D isoforms and the ATP-binding cassette (ABC) transporter ABCB1.{29520,29516}
Productname
IKK-16 (hydrochloride)
13313-50
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Productname
IKK-16 (hydrochloride)
13313-50
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