MPI-0441138
MPI-0441138 is a potent inducer of apoptosis and growth inhibition (EC50 = 2 nM for both processes, based on caspase-3 activation and total cellular ATP, respectively) in T47D and HCT116 cells.{16623,32891} MPI-0441138 has excellent blood brain barrier penetration and is effective in mouse xenograft cancer models.{16623,32891}
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