Pterostilbene

Pterostilbene is a polyketide synthase-derived stilbene originally isolated from P. santalinus that has diverse biological activities.{62166,17408,17413,17411,60517} It reduces photooxidative leakage induced by the herbicide acifluorfen in C. sativus cotyledon disks when used at a concentration of 30 µg/ml.{17408} Pterostilbene (25 and 50 µM) inhibits invasion and migration of HepG2 hepatoma cells induced by 12-O-tetradecanoylphorbol 13-acetate (TPA; Item No. 10008014).{17413} It inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in LPS-stimulated RAW 264.7 macrophages when used at concentrations of 10 and 20 µM.{17411} Pterostilbene (100 and 300 µM) activates peroxisome proliferator-activated receptor ? (PPAR?) in H4IIEC3 rat hepatoma cells.{60517} It decreases plasma glucose and LDL levels and increases plasma levels of HDL in a hamster model of hypercholesterolemia induced by a high-fat diet when administered in the diet at 25 ppm.