13,14-dihydro-15-keto Prostaglandin D2

13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 (Item No. 12010) which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.{5248} It also inhibits ion flux in a canine colonic mucosa preparation.{9769} In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11?-hydroxy compounds which have also undergone ?-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.{418,35}