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Phospho-Btk (Tyr551) (Clone: G12) rabbit mAb Biotin conjugate
12-4348
100 tests
€992
Legenda image
Peptide ELISA using BtkY551-G12-Biotin conjugate titered starting from 0.3 µg/mL shows binding to only Btk pY551 phospho peptide and no cross-reactivity to Btk Y551 non-phospho peptide or to control peptides.
Product description
Btk is a major node in the B-cell receptor signaling pathway, where it regulates B cell maturation, activation, survival, differentiation, and proliferation. Btk is activated by Src family kinases, including Lyn, which phosphorylates Btk at Tyr551. Upon phosphorylation at this site, Btk is recruited to the plasma membrane where autophosphorylation at Tyr223 occurs. The Btk signaling pathway is a major target of small molecule inhibitors for B-cell lymphoma, autoimmune diseases, and non-Hodgkin's lymphomas. These inhibitors either form a covalent bond at Cys481 in the ATP-binding site or serve as reversible inhibitors that bind the SH3 pocket and stabilize inactive Btk.
Specifications
Applications
FC, ELISA
Host
Rabbit
Clonality
Monoclonal
Clone
BtkY551-G12
Isotype
Rabbit IgG1k
Supplier
Abeomics
Shipping & storage
Storage temperature
2-8°C
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Phospho-Btk (Tyr551) (Clone: G12) rabbit mAb Biotin conjugate
12-4348
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Phospho-Btk (Tyr551) (Clone: G12) rabbit mAb Biotin conjugate
12-4348
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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