Toggle Nav
Phospho-Btk (Tyr551) (Clone: G12) rabbit mAb
12-4272
200 ul
€1318
Legenda image
Flow cytometric analysis of Ramos cells secondary antibody only negative control (blue) or untreated (red) or treated with pervanadate (green) using Phospho-Btk (Tyr551) antibody BtkY551-G12 at 0.1 µg/mL.
Product description
Btk is a major node in the B-cell receptor signaling pathway, where it regulates B cell maturation, activation, survival, differentiation, and proliferation. Btk is activated by Src family kinases, including Lyn, which phosphorylates Btk at Tyr551. Upon phosphorylation at this site, Btk is recruited to the plasma membrane where autophosphorylation at Tyr223 occurs. The Btk signaling pathway is a major target of small molecule inhibitors for B-cell lymphoma, autoimmune diseases, and non-Hodgkin's lymphomas. These inhibitors either form a covalent bond at Cys481 in the ATP-binding site or serve as reversible inhibitors that bind the SH3 pocket and stabilize inactive Btk.
Specifications
Applications
FC, ELISA
Host
Rabbit
Clonality
Monoclonal
Clone
BtkY551-G12
Isotype
Rabbit IgG1k
Supplier
Abeomics
Shipping & storage
Storage temperature
-20°C
Do you have any questions about this product?
Order your product by email
Productname
Phospho-Btk (Tyr551) (Clone: G12) rabbit mAb
12-4272
By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Request a sample
Productname
Phospho-Btk (Tyr551) (Clone: G12) rabbit mAb
12-4272
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Are you looking for specific products, alternatives or documentation?
