SB 277011A (hydrochloride)
SB 277011A is an antagonist of the dopamine D3 receptor (pKi = 8.0) that is at least 100-fold selective for D3 over other monoamine receptors (pKis = 6.0, 5.0, and 2, 5-HT1D and 5-HT1B respectively).{31910,31909,31908} It has high oral bioavailability and enters the central nervous system of the rat.{31910} SB 277011A has been shown to have potential benefits in animal models of schizophrenia and Parkinson’s disease.{31909,31907}
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