CP 945,598 (hydrochloride)
CP 945,598 (hydrochloride) is a selective antagonist of the cannabinoid receptor CB1 with a Ki value of 0.7 nM and demonstrates relatively low affinity for CB2 receptors (Ki = 7.6 µM).{32999,33000} It is reported to reverse cannabinoid agonist-mediated responses (i.e., hypo-locomotion, hypothermia, analgesia, and catalepsy), to reduce food intake, and to increase energy expenditure as well as fat oxidation in rats.{32999,33000}
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