SKF 86466 is an antagonist of ?2-adrenergic receptors (?2-ARs; Kis = 9.4, 16, and 20 nM for ?2A, ?2B, and ?2C receptors, respectively).{34495} It is selective for ?2-ARs over ?1-ARs (Kis = 449, 485, and 126 nM for ?1A, ?1B, and ?1D receptors, respectively). SKF 86466 inhibits contractions in rabbit aorta and canine saphenous vein induced by norepinephrine or B-HT 920 (Item No. 14177), respectively (KBs = 600 and 42 nM, respectively). It decreases diastolic blood pressure in DOCA-salt hypertensive, spontaneously hypertensive, and two kidney-one clip (2K-1C) renal hypertensive rats when administered at a dose of 2 mg/kg, i.v.{34494} SKF 86466 (1 mg/kg) reduces muscle rigidity induced by reserpine (Item No. 19474) in a mouse model of Parkinson’s disease.{34498}