LY266097 (hydrochloride)

LY266097 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B (Ki = 0.5 nM).{49230} It is selective for 5-HT2B over 5-HT2A and 5-HT2C receptors (Kis = 19.5 and 24.55 nM, respectively).{49231} LY266097 (100 nmol, intrathecal) reduces hind paw tactile allodynia induced by L5/L6 spinal nerve ligation in a rat model of neuropathic pain.{49232} It also reduces hyperlocomotion induced by cocaine in rats when administered at a dose of 0.63 mg/kg without reducing cocaine-induced dopamine outflow in the nucleus accumbens shell.{36202}