FPS-ZM1

FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; Ki = 25 nM).{21041} It blocks the binding of amyloid ? (A?) protein to RAGE and inhibits A?40- and A?42-induced cellular stress in RAGE-expressing cells.{21041} FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting ?-secretase activity, A? production, microglia activation, and neuroinflammation.{21041,33327} FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.{33328,33329}