Glutaredoxin 1 (human) Polyclonal Antibody - Biotinylated

Glutaredoxin 1 (Grx1) is a thiol-disulfide oxidoreductase and member of the thioredoxin family encoded by GLRX1 with a role in the maintenance of cellular thiol redox homeostasis.{53968} It is ubiquitously expressed and localizes to the cytosol, nucleus, and mitochondrial intermembrane space. Grx1 is a dithiol Grx that contains two active site cysteine residues, which catalyze the deglutathionylation of protein disulfides and glutathionylated proteins to regulate redox signal transduction and repair oxidized proteins.{49701,53969,49702} Knockdown or overexpression of GLRX1 enhances or reduces, respectively, oxidative stress-induced apoptosis in HEK293 T cells.{49703} Glrx1-/- mice have increased bronchoalveolar lavage fluid (BALF) macrophage infiltration and lung glutathionylated protein levels induced by cigarette smoke compared with wild-type mice.{49704} Grx1 levels are decreased in postmortem brain from patients with Parkinson's disease.{49702} Cayman’s Glutaredoxin 1 (human) Polyclonal Antibody - Biotinylated can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.