Indole-3-carbinol
Indole-3-carbinol (I3C) is a natural phytochemical produced in crucifers by the action of myrosinase on glucobrassinin.{32180} It has been shown to have anti-cancer effects, at least in part through inhibition of NF-?B and Akt signaling pathways.{32182} I3C may undergo a condensation reaction in vivo, leading to the production of 3,3’-diindolylmethane (Item No. 15927), which alters the expression of oncogenes and tumor suppressor genes.{32181}
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