L-798,106
Prostaglandin E2 (Item No. 14010) exerts its effects through four separate G-protein coupled receptors (EP1, EP2, EP3, and EP4).{1422} L-798,106 is a highly selective EP3 receptor antagonist with Ki values of 0.3, 916, >5,000, and >5,000 nM at EP3, EP4, EP1, and EP2, respectively.{9826} At 0.2 µM, it blocks the EP3 agonist activity of sulprostone (Item No. 14765) on guinea pig vas deferens and trachea.{26175}
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