Product description

CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.

Specifications
Applications
FC
Host
Mouse
Clonality
Monoclonal
Clone
EOS9.1
Isotype
Mouse IgM kappa
Supplier
Exbio
Product status
RUO
Shipping & storage
Storage temperature
2-8°C

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Anti-Hu CD95 Purified

11-753-C100

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Anti-Hu CD95 Purified

11-753-C100

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