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Anti-p53 Purified
11-114-C100
0,1 mg
€180
Product description
The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.
Specifications
Applications
FC, IP, IHC-P, WB, ELISA, ICC
Host
Mouse
Clonality
Monoclonal
Clone
BP53-12
Isotype
Mouse IgG2a
Supplier
Exbio
Product status
RUO
Shipping & storage
Storage temperature
2-8°C
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Anti-p53 Purified
11-114-C100
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Anti-p53 Purified
11-114-C100
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