CAY10641
Cytosolic phospholipase A2? (cPLA2?) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.{14663} CAY10641 is an inactive alcohol derivative of a highly potent (IC50 = 12 nM) cPLA2? inhibitor. {18732} The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.{18732} CAY10641 is rapidly cleared from the blood stream (only 0.5 ?g/ml remains 30 minutes after 10 mg/kg intravenous administration to mice).{18732} However, no other biological effects have been reported.
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