Onalespib
Onalespib is a selective inhibitor of Hsp90 (IC50 = 18 nM).{18725} It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo.{18725,33082} Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models.{33082}
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