LP-533401
LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that blocks the biosynthesis of gut-derived serotonin, completely inhibiting serotonin production in Tph1-expressing cells at a dose of 1 µM.{32686} It prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized and aged mice.{32686,32684} LP-533401 has also been used to elucidate the role of gut-derived serotonin in pulmonary hypertension and leukemia in mice.{32683,32685}
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