11B-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide
11-Hydroxysteroid dehydrogenase type 2 (11?-HSD2) plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11?-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.{11854} Expression of 11?-HSD2 mRNA and protein has been shown in placenta and mineralocorticoid target tissues, particularly the kidney.{12000} In mouse, expression of this enzyme is tissue- and developmentally specific, indicating the importance of the enzyme in regulating glucocorticoid-mediated maturation.{11999} Cayman’s 11?-HSD2 polyclonal antibody detects a band at around 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.
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11B-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide
10242-200
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11B-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide
10242-200
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