Product description

GPR55 is an orphan G protein-coupled receptor.{53310} GPR55 is expressed in the brain, large dorsal root ganglion neurons, and many peripheral tissues.{53311,17584} Endogenous agonists for GPR55 include lysophosphatidylinositol (EC50 = 1.2 µM in a ?-arrestin-GFP biosensor assay) and the endocannabinoids anandamide (arachidonoyl ethanolamide; Item No. 90050) and 2-arachidonoyl glycerol (Item No. 62160; EC50s = 18.4 and 3.5 nM in GTP?S binding assays).{53310,53312} It is also activated by the cannabinoid ?9-tetrahydrocannabinol (?9-THC; EC50 = 8 nM in a GTP?S binding assay).{53310,17581} GPR55 is expressed in ? cells and pharmacological activation increases glucose-induced insulin release in wild-type mice and, to a lesser extent, in Gpr55 knockout mice.{53313} GPR55 expression is increased in the visceral adipose tissue of obese patients and, to a larger extent, in obese patients with type-2 diabetes.{53314} Activation of GPR55 increases the growth and invasiveness of cancer cells in vitro, and its expression in patient-derived tumors is positively correlated with a worse prognosis.{53313} GPR55 activation has also been associated with inhibition of osteoclast formation. Cayman’s GPR55 Polyclonal Antibody can be used for flow cytometry, immunofluorescence, and Western blot applications. The antibody recognizes GPR55 at 37 kDa from human and bovine samples. Post-translational modifications such as glycosylation may retard receptor electrophoretic migration such that the protein signal may be detected above 37 kDa.

Specifications
Applications
WB, ELISA
Host
Rabbit
Clonality
Polyclonal
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

Order your product by email

Productname

GPR55 Polyclonal Antibody

10224-1

By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Request a sample

Productname

GPR55 Polyclonal Antibody

10224-1

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Organization information

*Required fields


Are you looking for specific products, alternatives or documentation?