FP Receptor Polyclonal Antibody

The prostaglandin F2? receptor (FP receptor) is a G protein-coupled receptor known to elicit smooth muscle contraction in a variety of tissues.{9114} FP receptor mRNA is found in reproductive, gastric, neural, and ocular tissues as well as specialized cells of the kidney.{3160,1374,1680,9666} Two FP receptor isoforms, FPA and FPB have been identified in sheep.{3905} FPB receptor is truncated at the carboxy-terminus thereby preventing desensitization (which normally occurs by protein kinase C phosphorylation of FPA) and produces aberrant signalling in FPB transfectants.{7614,9285} The existence of a truncated human FP isoform responsible for signal-amplification contributing to luteolysis, cell growth, or malignant transformation is currently unknown.{3905,7614,9285,4688} Cayman’s FP Receptor Polyclonal Antibody can be used for Western blot applications. The calculated size of FP Receptor is 41 kDa and this antibody recognizes multiple bands from 50-67 kDa from human, bovine, mouse, ovine, and rat samples.