LAMP-1/CD107a Monoclonal Antibody

Lysosome-associated membrane protein 1 (LAMP-1), also known as CD107a, is an abundant lysosomal integral membrane glycoprotein.{51231} It is composed of a signal peptide, two LAMP-like domains that are separated by a proline-rich hinge region, a transmembrane domain, and a C-terminal tail that contains a YXXI tyrosine-based motif, which is required for targeting of LAMP-1 to the lysosome.{51231,15783} LAMP-1 is ubiquitously expressed and localizes to lysosomes, endosomes, and the plasma membrane.{51232,15783} It is involved in human peripheral blood mononuclear cells (PBMC) adhesion to vascular endothelium, natural killer (NK) cell degranulation, virus entry, and cancer progression and metastasis.{15784,51233,51234,51235} Homozygous knockout of Lamp1 prevents Lassa virus infection in mice.{51234} Pulmonary protein levels of LAMP-1 are increased in patients with chronic obstructive pulmonary disease (COPD), and increased LAMP-1 lung levels positively correlate with smoking history and negatively correlate with lung function.{51236} Cayman's LAMP-1/CD107a Monoclonal Antibody (Clone Ly1C6) can be used for immunocytochemistry (ICC), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes LAMP-1 at approximately 120 kDa from rat and hamster samples.