NH125
NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria.{16459} In bacteria, NH125 inhibits several histidine kinases, inhibiting YycG with an IC50 of 6.6 µM.{16460} NH125 also decreases the viability of several cancer cell lines with IC50 values ranging from 0.7-4.7 µM.{16458} In mammalian cells, NH125 strongly inhibits eEF-2K (IC50 = 60 nM), with weaker effects on protein kinase C (IC50 = 7.5 µM), protein kinase A (IC50 = 80 µM), and calmodulin-dependent kinase II (IC50 = 100 µM).{16458}
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