PD 146176
PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1.{16748} It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells.{16748,16747,16745} PD 146176 inhibits amyloid ? protein aggregate formation without changing total levels of amyloid ? precursor protein (APP) in cells stably expressing APP.{16746} In addition, it lacks significant non-specific antioxidant properties.{16747}
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