Raf-1 (Phospho-Ser642) Polyclonal Antibody
The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK.{14542} Previous studies have shown that phosphorylation is required for Raf-1 activation.{14329,14539} Recent work has demonstrated that phosphorylation also regulates the down regulation of Raf with two sites participating: Ser301 and Ser642.{14540}
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Raf-1 (Phospho-Ser642) Polyclonal Antibody
10009505-1
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Raf-1 (Phospho-Ser642) Polyclonal Antibody
10009505-1
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