CREB (Phospho-Ser133) Polyclonal Antibody

It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus.{14339} The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors.{14341} This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory.{14342,14343} A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 is required for CREB-mediated transcription.{14338,14340}