CAY10573

The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent binding at PPAR?, ?, and ? with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPAR?, ?, and ? with EC50 values of 8, 70, and 500 nM, respectively.{14166} CAY10573 demonstrates stronger binding and functional activity for PPAR? than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM).{14166}