2,3-bis (4-Hydroxyphenyl) Propionitrile

2,3-bis(4-Hydroxyphenyl)propionitrile (DPN) is an estrogen receptor ? (ER?) selective agonist. DPN exhibits a 70-fold higher relative binding affinity for ER? (18%) versus ER? (0.25%), about 80-fold higher transcriptional potency (EC50 = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays.{14165} Based on this selectivity, DPN is commonly used as a tool to evaluate the biological role of ER?.