Celecoxib

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50 = 0.05 µM).{11633} It is selective for COX-2 over COX-1 (IC50 = 22.9 µM).{11633,8926} Celecoxib induces apoptosis in BJAB and Jurkat cancer cells in a concentration-dependent manner.{12660} It reduces blood glucose levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{41722} Celecoxib reduces the latency to escape and the path length in the Morris water maze, as well as increases BDNF and tropomyosin-related kinase B (TrkB) protein levels in the hippocampus, in the same model. It inhibits the production of IL-1? and TNF-? and reduces synovial fluid expression of the gene encoding matrix metalloproteinase-3 (MMP-3) in a rabbit model of osteoarthritis when administered intra-articularly.{41721} Celecoxib (100 mg/kg per day) increases serum levels of lactate dehydrogenase (LDH), troponin-T, TNF-?, and creatine kinase-MB (CK-MB), markers of cardiotoxicity, in rats.{69167} Formulations containing celecoxib have been used in the treatment of osteoarthritis, and rheumatoid arthritis, and as an analgesic.