Peroxisome proliferator-activated receptor-? (PPAR?) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.{6374,4136} Activation of PPAR? results in expression of a variety of genes, particularly those involved in fatty acid ?-oxidation, binding, and transport.{11955} GW 7647 is a potent, selective agonist of human and murine PPAR?{14085} It activates human PPAR?, PPAR?, and PPAR? with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.{14085}