a-Tocotrienol

?-Tocotrienol is an antioxidant and a form of vitamin E that has been found in rice bran and has neuroprotective properties.{3679,14290,14292,52764} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} Cytosolic microinjection of ?-tocotrienol prevents glutamate-induced cell death and phosphorylation of 12-lipoxygenase (12-LO) in HT4 neurons.{14292} It reduces glutamate-induced cytosolic and mitochondrial production of reactive oxygen species (ROS), accumulation of N-terminally truncated Bcl-xL (?N-Bcl-xL), and cell death in primary rat hippocampal neurons.{52764} ?-Tocotrienol (50 mg/kg) reduces infarct size in a spontaneously hypertensive rat model of stroke induced by tandem right common carotid artery and middle cerebral artery occlusion.{14292} [Matreya, LLC. Catalog No. 2109]