PPARd (human, recombinant)

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family of ligand activated transcription factors that heterodimerize with retinoic acid like receptors, regulating gene expression and differentiation.{7654} The PPAR family of nuclear hormone receptors consists of three subtypes encoded by separate genes: PPAR?, PPAR? (also referred to as hNUC1, PPAR?, or FAAR), and PPAR?. PPAR? is ubiquitously expressed but is particularly abundant in tissues such as liver, intestine, kidney, abdominal adipose, and skeletal muscle, all of which are involved in lipid metabolism.{10670} PPAR? is a mediator of diverse physiological functions including lipid and cholesterol homeostasis, embryo implantation, and cancer development.{6570,7166,9142,7771} Most recently, attention has been focused on the role of PPAR? in obesity.{11581} Cayman’s PPAR? protein is purified from a baculovirus overexpression system. The purity was determined using gel electrophoresis followed by coomassie staining.