(+-)19(20)-DiHDPA
Docosahexaenoic acid (DHA; Item No. 90310) is an essential fatty acid and the most abundant ?-3 fatty acid in neural tissues, especially in the retina and brain.{10297} (±)19(20)-DiHDPA is one of the major metabolites produced when DHA is incubated with NADPH-supplemented rat liver microsomes.{7480} DHA is also slowly metabolized by monkey seminal vesicles to (±)19(20)-DiHDPA.{13151} The route of production likely proceeds through cytochrome P450-catalyzed epoxidation at the ?-3 double bond, followed by conversion to the vicinal diols by epoxide hydrolase.{7480,13151}
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