PD 98059
PD 98059 is a noncompetitive inhibitor of the MAPK pathway.{12847,10421} It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAP2K1.{13126} It inhibits Raf activation of MAP2K2 with an IC50 value of 50 µM.{13126} PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
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PD 98059
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