Losartan (potassium salt)

Losartan is an antagonist of angiotensin II type 1b (AT1b) receptor (IC50 = 2.2 nM in COS-7 cells expressing the rat receptor).{12997} It reduces U-46619-induced aggregation of platelets in isolated human platelet-rich plasma when used at a concentration of 5 µM.{67398} It decreases 1-lipoxygenase (1-LO) levels in the endothelial layer of autologous vein grafts in rabbits fed a high-cholesterol diet when administered at a dose of 10 mg/kg per day.{12998} Losartan (15 mg/kg per day) decreases systolic blood pressure in a ouabain-induced mouse model of hypertension.{13089} It also increases the mechanical pain threshold in the von Frey test in a paclitaxel-induced rat model of neuropathic pain when administered at a dose of 50 mg/kg twice per day.{67399} Formulations containing losartan have been used in the treatment of hypertension and diabetic nephropathy.