CB1 Receptor (C-Term) Blocking Peptide

To be used in conjunction with Cayman’s CB1 Receptor (C-Term) polyclonal antibody (Item No. 10006590) to block protein-antibody complex formation during immunochemical analysis of CB1 · The CB1 receptor is a G-protein coupled receptor that binds the active component of cannabis, ?9-tetrahydrocannabinol.{6749,6747} Human and rat CB1 receptors exhibit 97.3% homology at the amino acid level over the complete protein, and 100% homology within the peptide sequence used to make the Cayman CB1 Receptor polyclonal antibody (Item No. 10006590).{6629,6628} This peptide exhibits no homology with the CB2 receptor. Based on the amino acid sequence, the CB1 receptor has a molecular weight of approximately 52,800.{6628} The CB1 receptor and the splice variant CB1a are localized mainly in the brain whereas the CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hematopoietic cells.{6629,6628,6726,6727}