Oleyl Anilide
Oleyl anilide is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 26 µM).{12463} It induces splenomegaly in C57BL/6 mice and leads to weakness, weight loss, cachexia, and death in A/J mice with increases in serum IgG and IgM levels in both strains.{65166} Oleyl anilide has been found in aniline-denatured rapeseed cooking oil, which has been associated with toxic oil syndrome, a chemically induced autoimmune syndrome characterized by acute pulmonary inflammation and eosinophilia, severe myalgia, and chronic peripheral neuropathy.{13123,65167,65168}
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