NO-Losartan A
Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.{12997} In humans, losartan effectively controls hypertension while protecting renal function.{12996} Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.{6818,13090} NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.{12442}
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