Hypoxia-inducible factor-1? (HIF-1?) is a transcription factor that accumulates under low-oxygen conditions.{10948,11044} Following hypoxic stimulus and cytoplasmic accumulation, HIF-1? migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.{11044,9833,9834,9835,10695} HIF-1? is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities.{11043,10898} Cayman Chemical’s HIF-1? polyclonal antibody can be used for WB analysis for HIF-1? on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested.
Productname
HIF-1a (C-Term) Polyclonal Antibody
10006421-1
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Productname
HIF-1a (C-Term) Polyclonal Antibody
10006421-1
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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