BCTC

The vanilloid receptor 1 (TRPV1) is a ligand-gated ion channel highly expressed on primary nociceptive neurons that respond to a variety of noxious stimuli, including heat, acid, and other chemical irritants. Because disruptions in TRPV1 activity cause reduced thermal nociception and hyperalgesia, this receptor is considered to be a useful target for the discovery of novel analgesics. BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.{12337,14470}