Renin (human, recombinant)

Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone.{57726} It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activity. It is formed from prorenin, a zymogen found primarily in the juxtaglomerular cells in the kidney, by proteolytic removal of its autoinhibitory domain.{12970,57727} Renin catalyzes the conversion of angiotensinogen to angiotensin I, which is the first and rate-limiting step of the renin-angiotensin system (RAS) responsible for regulating blood pressure.{57727} When blood pressure is low, renin secretion is increased and the RAS is activated, which increases arterial vasoconstriction and sodium resorption to maintain blood pressure at homeostatic levels.{13007} Deletion or substitution of the leucine in position 16 of REN, the gene encoding renin, that reduce or eliminate renin biosynthesis are associated with multiple inflammatory diseases, including chronic kidney failure and early-onset hyperuricemia.{57728} Cayman's Renin (human, recombinant) protein can be used for enzyme assay and Western blot applications.